Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial‑mesenchymal transition

21 Aug 2019

Abstract excerpt

The aberrant expression of tumor suppressor Smad4 often occurs in colorectal cancer (CRC), and this phenomenon is believed to be associated with drug resistance. The present study aimed to investigate the effects of Smad4 on the sensitivity of CRC cells to cetuximab, and the possible mechanism underlying such an effect. A total of 629 colorectal adenocarcinoma cases were downloaded from The Cancer Genome Atlas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Pancreatic and Hepatic Oncology Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31485652
DOI: 10.3892/mmr.2019.10597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial‑mesenchymal transitionPMID 31485652Read ↗

TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRCSemantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysisSemantic proximity Read ↗

Assessment of the Influence of 5-fluorouracil on the SMAD4 Gene Expression, Apoptosis induction and DNA Damage in the Human CACO-2 Cell LineSemantic proximity Read ↗

Correlation Between SMADs and Colorectal Cancer Expression, Prognosis, and Immune InfiltratesSemantic proximity Read ↗

Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathwaysSemantic proximity Read ↗

Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysisSemantic proximity Read ↗

Smad4 and epithelial–mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical studySemantic proximity Read ↗

NME4 promotes cell malignant process by targeting SMAD2 in colorectal cancerSemantic proximity Read ↗

Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancerSemantic proximity Read ↗

Hsa-miR-186-5p regulates TGFβ signaling pathway through expression suppression of SMAD6 and SMAD7 genes in colorectal cancerSemantic proximity Read ↗

Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.