Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMAD4 levels and response to 5-fluorouracil in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2005

Alhopuro Pia, Alazzouzi Hafid, Sammalkorpi Heli, Dávalos Verónica, Salovaara Reijo, Hemminki Akseli, Järvinen Heikki, Mecklin Jukka-Pekka, Schwartz Simo, Aaltonen Lauri A, Arango Diego

Abstract excerpt

We have recently reported that low tumor levels of SMAD4, a key mediator of transforming growth factor-beta superfamily signaling, can predict the probability of recurrence in patients with Dukes C colorectal cancer who had surgery as the only form of treatment. However, standard treatment for Dukes C colorectal cancer patients currently involves the administration of 5-fluorouracil (5-FU)-based adjuvant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance
Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotherapy, Adjuvant

Share to Chromosomes, Human, Pair 18

Share to Fluorouracil

Share to Immunoenzyme Techniques

Share to Lymphatic Metastasis

Share to Smad4 Protein

Source

Identifiers

PMID: 16144935
DOI: 10.1158/1078-0432.CCR-05-0244

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMAD4 levels and response to 5-fluorouracil in colorectal cancer.PMID 16144935Read ↗

SMAD4 as a prognostic marker in colorectal cancer.Semantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysisSemantic proximity Read ↗

Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon CancerSemantic proximity Read ↗

Smad4 Inactivation Promotes Malignancy and Drug Resistance of Colon CancerSemantic proximity Read ↗

A SMAD4 ‐modulated gene profile predicts disease‐free survival in stage II and III colorectal cancerSemantic proximity Read ↗

Loss of Smad4 expression predicts liver metastasis in human colorectal cancer.Semantic proximity Read ↗

Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial‑mesenchymal transitionSemantic proximity Read ↗

Assessment of the Influence of 5-fluorouracil on the SMAD4 Gene Expression, Apoptosis induction and DNA Damage in the Human CACO-2 Cell LineSemantic proximity Read ↗

Smad4 and epithelial–mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical studySemantic proximity Read ↗

High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosisSemantic proximity Read ↗

SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.