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Article

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis.

BMC gastroenterology - 23 Jul 2021

Fang Tian, Liang Tingting, Wang Yizhuo, Wu Haitao, Liu Shuhan, Xie Linying, Liang Jiaying, Wang Chang, Tan Yehui

Abstract excerpt

BACKGROUND: Approximately 5.0-24.2% of colorectal cancers (CRCs) have inactivating mutations in SMAD4, making it one of the frequently mutated genes in CRC. We thus carried out a comprehensive system review and meta-analysis investigating the prognostic significance and clinicopathological features of SMAD4 gene mutation in CRC patients. METHODS: A detailed literature search was conducted in PubMed, Web of...

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Identifiers

PMID: 34301194
DOI: 10.1186/s12876-021-01864-9
PMCID: PMC8299661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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