Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.

doi:10.1161/CIRCEP.109.862649

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Article

Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.

Circulation. Arrhythmia and electrophysiology - 1 Oct 2009

Itoh Hideki, Sakaguchi Tomoko, Ding Wei-Guang, Watanabe Eiichi, Watanabe Ichiro, Nishio Yukiko, Makiyama Takeru, Ohno Seiko, Akao Masaharu, Higashi Yukei, Zenda Naoko, Kubota Tomoki, Mori Chikara, Okajima Katsunori, Haruna Tetsuya, Miyamoto Akashi, Kawamura Mihoko, Ishida Katsuya, Nagaoka Iori, Oka Yuko, Nakazawa Yuko, Yao Takenori, Jo Hikari, Sugimoto Yoshihisa, Ashihara Takashi, Hayashi Hideki, Ito Makoto, Imoto Keiji, Matsuura Hiroshi, Horie Minoru

Abstract excerpt

BACKGROUND: Drugs with I(Kr)-blocking action cause secondary long-QT syndrome. Several cases have been associated with mutations of genes coding cardiac ion channels, but their frequency among patients affected by drug-induced long-QT syndrome (dLQTS) and the resultant molecular effects remain unknown. METHODS AND RESULTS: Genetic testing was carried out for long-QT syndrome-related genes in 20 subjects with...

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PMID: 19843919
DOI: 10.1161/CIRCEP.109.862649

Genes

KCNH2
KCNQ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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