Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.

Cardiovascular research - 1 May 2001

Clancy C E, Rudy Y

Abstract excerpt

BACKGROUND: A variety of mutations in HERG, the major subunit of the rapidly activating component of the cardiac delayed rectifier I(Kr), have been found to underlie the congenital Long-QT syndrome, LQT2. LQT2 may give rise to severe arrhythmogenic phenotypes leading to sudden cardiac death. OBJECTIVE: We attempt to elucidate the mechanisms by which heterogeneous LQT2 genotypes can lead to prolongation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Death, Sudden, Cardiac
Share to ERG1 Potassium Channel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ether-A-Go-Go Potassium Channels

Share to Markov Chains

Share to Models, Cardiovascular

Share to Potassium Channels, Voltage-Gated

Share to Transcriptional Regulator ERG

Source

Identifiers

PMID: 11334834
DOI: 10.1016/s0008-6363(00)00293-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death.PMID 11334834Read ↗

Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues.Semantic proximity Read ↗

Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2.Semantic proximity Read ↗

Distinct gene-specific mechanisms of arrhythmia revealed by cardiac gene transfer of two long QT disease genes, HERG and KCNE1.Semantic proximity Read ↗

Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel.Semantic proximity Read ↗

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndromeSemantic proximity Read ↗

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.Semantic proximity Read ↗

Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.Semantic proximity Read ↗

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.Semantic proximity Read ↗

Modelling and imaging cardiac repolarization abnormalities.Semantic proximity Read ↗

Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.Semantic proximity Read ↗

Sudden Death Associated With Short-QT Syndrome Linked to Mutations in HERGSemantic proximity Read ↗

Elevated heart rate triggers action potential alternans and sudden death. translational study of a homozygous KCNH2 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.