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Article

Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.

The Journal of experimental medicine - 7 Mar 2016

Misra Ashish, Sheikh Abdul Q, Kumar Abhishek, Luo Jiesi, Zhang Jiasheng, Hinton Robert B, Smoot Leslie, Kaplan Paige, Urban Zsolt, Qyang Yibing, Tellides George, Greif Daniel M

Abstract excerpt

The aorta is the largest artery in the body, yet processes underlying aortic pathology are poorly understood. The arterial media consists of circumferential layers of elastic lamellae and smooth muscle cells (SMCs), and many arterial diseases are characterized by defective lamellae and excess SMCs; however, a mechanism linking these pathological features is lacking. In this study, we use lineage and genetic...

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Source

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Identifiers

PMID: 26858344
DOI: 10.1084/jem.20150688
PMCID: PMC4813675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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