Article
A critical role for elastin signaling in vascular morphogenesis and disease.
Development (Cambridge, England) - 1 Jan 2003
Karnik Satyajit K, Brooke Benjamin S, Bayes-Genis Antonio, Sorensen Lise, Wythe Joshua D, Schwartz Robert S, Keating Mark T, Li Dean Y
Abstract excerpt
Vascular proliferative diseases such as atherosclerosis and coronary restenosis are leading causes of morbidity and mortality in developed nations. Common features associated with these heterogeneous disorders involve phenotypic modulation and subsequent abnormal proliferation and migration of vascular smooth muscle cells into the arterial lumen, leading to neointimal formation and vascular stenosis. This...
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