Article

Loss of presenilin-1 in smooth muscle cells ameliorates elastin aortopathy

2023-04-15

Abstract excerpt

Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, such as atherosclerosis, pulmonary hypertension and supravalvular aortic stenosis (SVAS). We previously demonstrated that elastin insufficiency activates the Notch pathway in aortic SMCs, resulting in hypermuscularization. Activation of Notch is catalyzed by the enzyme gamma-secretase, but the role of speci...

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Literature Corpus work: 4192aaab-7133-52a1-834b-7061b4a3355b
DOI: 10.1101/2023.04.15.536809

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