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Article

Mechanics of ascending aortas from TGFβ-1, -2, -3 haploinsufficient mice and elastase-induced aortopathy.

Journal of biomechanics - 26 Aug 2021

Lane Brooks A, Chakrabarti Mrinmay, Ferruzzi Jacopo, Azhar Mohamad, Eberth John F

Abstract excerpt

Transforming growth factor-beta (TGFβ-1, -2, -3) ligands act through a common receptor complex yet each is expressed in a unique and overlapping fashion throughout development. TGFβ plays a role in extra-cellular matrix composition with mutations to genes encoding TGFβ and TGFβ signaling molecules contributing to diverse and deadly thoracic aortopathies common in Loeys-Dietz syndrome (LDS). In this investigation,...

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Identifiers

PMID: 34174532
DOI: 10.1016/j.jbiomech.2021.110543
PMCID: PMC8355174

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