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Article

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

Journal of the National Cancer Institute - 1 May 2016

Schirmer Markus A, Lüske Claudia M, Roppel Sebastian, Schaudinn Alexander, Zimmer Christian, Pflüger Ruben, Haubrock Martin, Rapp Jacobe, Güngör Cenap, Bockhorn Maximilian, Hackert Thilo, Hank Thomas, Strobel Oliver, Werner Jens, Izbicki Jakob R, Johnsen Steven A, Gaedcke Jochen, Brockmöller Jürgen, Ghadimi B Michael

Abstract excerpt

BACKGROUND: A genome-wide association study (GWAS) suggested inherited genetic single-nucleotide polymorphisms (SNPs) affecting overall survival (OS) in advanced pancreatic cancer. To identify robust clinical biomarkers, we tested the strongest reported candidate loci in an independent patient cohort, assessed cellular drug sensitivity, and evaluated molecular effects. METHODS: This study comprised 381 patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26857392
DOI: 10.1093/jnci/djv387
PMCID: PMC4859408

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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