SLCO1B1 Polymorphism Is a Drug Response Predictive Marker for Advanced Pancreatic Cancer Patients Treated With Gemcitabine, S-1, or Gemcitabine Plus S-1.

doi:10.1097/MPA.0000000000001052

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SLCO1B1 Polymorphism Is a Drug Response Predictive Marker for Advanced Pancreatic Cancer Patients Treated With Gemcitabine, S-1, or Gemcitabine Plus S-1.

Pancreas - 1 Jan 2000

Sato Yasunori, Ueno Hideki, Ioka Tatsuya, Ohkawa Shinichi, Ikeda Masafumi, Shimamura Tomotaka, Tsuji Akihito, Tsuchiya Yoshiaki, Furuse Junji, Ishii Hiroshi, Furuya Ken, Iguchi Haruo, Saito Yoshihiro, Kaniwa Nahoko, Sawada Jun-Ichi, Sakamoto Hiromi, Sekine Akihiro, Okusaka Takuji, Yoshida Teruhiko

Abstract excerpt

OBJECTIVES: The aim of this study was to evaluate the effects of single-nucleotide polymorphisms (SNPs) on advanced pancreatic cancer risk and overall survival (OS) in a candidate-gene approach. METHODS: Overall, 5438 SNPs in 219 candidate genes encoding several drug-metabolizing enzymes or transporters were analyzed. In the screening study, 3 SNPs were found associated with OS (P ≤ 0.0005). We validated these...

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PMID: 29683977
DOI: 10.1097/MPA.0000000000001052

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