Article
Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk.
Oncotarget - 25 Oct 2016
Cheng Hsin-Lin, Liu Yu-Fan, Su Chun-Wen, Su Shih-Chi, Chen Mu-Kuan, Yang Shun-Fa, Lin Chiao-Wen
Abstract excerpt
In Taiwan, oral cancer is the fourth leading cancer in males and is associated with exposure to environmental carcinogens. WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, is associated with the development of various cancers. We hypothesized that genetic variants of WWOX influence the susceptibility to oral cancer. Five polymorphisms of WWOX gene from 761 male patients with oral cancer and...
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