Article
The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
PloS one - 1 Jan 2018
Innocenti Federico, Owzar Kouros, Jiang Chen, Etheridge Amy S, Gordân Raluca, Sibley Alexander B, Mulkey Flora, Niedzwiecki Donna, Glubb Dylan, Neel Nicole, Talamonti Mark S, Bentrem David J, Seiser Eric, Yeh Jen Jen, Van Loon Katherine, McLeod Howard, Ratain Mark J, Kindler Hedy L, Venook Alan P, Nakamura Yusuke, Kubo Michiaki, Petersen Gloria M, Bamlet William R, McWilliams Robert R
Abstract excerpt
PURPOSE: Advanced pancreatic cancer is a highly refractory disease almost always associated with survival of little more than a year. New interventions based on novel targets are needed. We aim to identify new genetic determinants of overall survival (OS) in patients after treatment with gemcitabine using genome-wide screens of germline DNA. We aim also to support these findings with in vitro functional analysis....
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