Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2010

Paige Adam J W, Zucknick Manuela, Janczar Szymon, Paul Jim, Mein Charles A, Taylor Karen J, Stewart Moira, Gourley Charlie, Richardson Sylvia, Perren Timothy, Ganesan Trivadi S, Smyth John F, Brown Robert, Gabra Hani

Abstract excerpt

WWOX is a bona fide tumour suppressor, with hypomorphic and knockout mouse models exhibiting increased tumour susceptibility. In ovarian cancer cells WWOX transfection abolishes tumourigenicity, suppresses tumour cell adhesion to extracellular matrix and induces apoptosis in non-adherent cells. O...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Neoplasm Staging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ovarian Neoplasms

Share to Oxidoreductases

Share to Prognosis

Share to Survival Analysis

Share to Tumor Suppressor Proteins

Share to WW Domain-Containing Oxidoreductase

Source

Identifiers

PMID: 20074932
DOI: 10.1016/j.ejca.2009.12.021

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20074932-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis.PMID 20074932Read ↗

WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancerSemantic proximity Read ↗

WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclearSemantic proximity Read ↗

WWOX: a candidate tumor suppressor gene involved in multiple tumor types.Semantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

Wwox inactivation enhances mammary tumorigenesis.Semantic proximity Read ↗

WWOX: a fragile tumor suppressor.Semantic proximity Read ↗

Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

Relationship between PIWIL1 gene polymorphisms and epithelial ovarian cancer susceptibility among southern Chinese woman: a three-center case-control study.Semantic proximity Read ↗

Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk.Semantic proximity Read ↗

Relationship of common variants in WWOX gene with susceptibility and prognosis of Prostate cancerSemantic proximity Read ↗

Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk.Semantic proximity Read ↗

Targeted deletion of Wwox reveals a tumor suppressor function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.