NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer.

doi:10.1093/jnci/djaf345

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Article

NQO1 as a predictor of response to adjuvant GemCap treatment for pancreatic cancer.

Journal of the National Cancer Institute - 1 Apr 2026

Williams Dylan, Patel Chandni, Murray Kate, Oldfield Lucy, Small Benjamin, Barrera Lawrence N, O'Sullivan Rachel, Birch-Ford James, Evans Anthony, Campbell Fiona, Perez-Mancera Pedro A, Halloran Christopher M, Palmer Daniel, Greenhalf William, Copple Ian M, Goldring Chris, Hackert Thilo, Jackson Richard, Neoptolemos John P, Springfeld Christoph, Büchler Markus W, Michalski Christoph W, Ghaneh Paula, Costello Eithne

Abstract excerpt

BACKGROUND: NAD(P)H quinone dehydrogenase 1 (NQO1), a detoxification enzyme regulated by the Nrf2 cytoprotective pathway, is overexpressed in pancreatic ductal adenocarcinoma (PDAC). NQO1 levels are also influenced by the C609T single-nucleotide polymorphism (SNP). We hypothesized that elevated N...

Topics

NAD(P)H Dehydrogenase (Quinone)
Pancreatic Neoplasms
Humans
Animals
Deoxycytidine
Gemcitabine
Mice
Polymorphism, Single Nucleotide
NF-E2-Related Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Carcinoma, Pancreatic Ductal

Fluorouracil

Drug Resistance, Neoplasm

Chemotherapy, Adjuvant

Antineoplastic Combined Chemotherapy Protocols

Female

Male

Cell Line, Tumor

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 41324572
DOI: 10.1093/jnci/djaf345
PMCID: PMC13064515

Genes

NQO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41324572-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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