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The high identity of the Trypanosoma cruzi Group‐I of trans‐sialidases points them as promising vaccine immunogens

16 Jun 2023

Abstract excerpt

Abstract Trans‐sialidase (TS) superfamily of proteins comprises eight subgroups, being the proteins of Group‐I (TS‐GI) promising immunogens in vaccine approaches against Trypanosoma cruzi. Strikingly, TS‐GI antigenic variability among parasite lineages and their influence on vaccine development has not been previously analyzed. Here, a search in GenBank detects 49 TS‐GI indexed sequences, whereas the main...

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PMID: 37323089
DOI: 10.1002/prot.26537

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