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Rational <i>in silico</i> discovery and serological validation of <i>Trypanosoma cruzi</i> -specific B-cell epitopes for high-precision Chagas disease diagnosis

2026-03-11

Abstract excerpt

Chagas disease is caused by the parasite Trypanosoma cruzi and remains a neglected tropical disease presenting a substantial global health burden. Crude antigen-based assays have historically been limited in specificity; however, even contemporary recombinant-antigen tests may exhibit residual cross-reactivity, depending on antigen composition and geographic context. To overcome this limitation, this study develo...

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Literature Corpus work
47b355a9-b84b-5fa9-9bfc-18e83ad8da4a
DOI
10.64898/2026.03.09.710567
Open publication

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Rational <i>in silico</i> discovery and serological validation of <i>Trypanosoma cruzi</i> -specific B-cell epitopes for high-precision Chagas disease diagnosisDOI 10.64898/2026.03.09.710567
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