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Article

Regulation of Memory Formation by the Transcription Factor XBP1

1 Feb 2016

Abstract excerpt

Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar disorders. XBP1 is a major regulator of the unfolded protein response (UPR), mediating adaptation to endoplasmic reticulum (ER) stress. Using a phenotypic screen, we uncovered an unexpected function...

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PMID: 26854229
DOI: 10.1016/j.celrep.2016.01.028

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