Article

Endoplasmic Reticulum Chaperone Genes Encode Effectors of Long-Term Memory

2021-10-21

Abstract excerpt

The mechanisms underlying memory loss associated with Alzheimer’s disease and related dementias (ADRD) remain unclear, and no effective treatments exist. Fundamental studies have shown that a set of transcriptional regulatory proteins of the nuclear receptor 4a (Nr4a) family serve as molecular switches for long-term memory. Here, we show that Nr4a proteins regulate the transcription of a group of genes encoding ch...

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Literature Corpus work: 717ef535-52bc-576f-b4aa-7b121999cdac
DOI: 10.1101/2021.10.20.465191

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