Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

1 Feb 2016

Abstract excerpt

Factors linking inflammation and cancer are of great interest. We now report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (H2Bub1), modulates inflammation and inflammation-associated cancer in mice and humans. Downregulation of RNF20 and H2Bub1 favors recruitment of p65-containing nuclear factor κB (NF-κB) dimers over repressive p50 homodimers and decreases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26854224
DOI: 10.1016/j.celrep.2016.01.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated CancerPMID 26854224Read ↗

NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitisSemantic proximity Read ↗

Loss of H2B monoubiquitination is associated with poor‐differentiation and enhanced malignancy of lung adenocarcinomaSemantic proximity Read ↗

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.Semantic proximity Read ↗

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in CancerSemantic proximity Read ↗

The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cellsSemantic proximity Read ↗

A20 in inflammation and autoimmunity.Semantic proximity Read ↗

The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe?Semantic proximity Read ↗

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.Semantic proximity Read ↗

A20 Restricts Wnt Signaling in Intestinal Epithelial Cells and Suppresses Colon CarcinogenesisSemantic proximity Read ↗

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.Semantic proximity Read ↗

A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven EnteritisSemantic proximity Read ↗

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.