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The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells

2 Jul 2019

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide, and deciphering underlying molecular mechanism is essential. The loss of monoubiquitinated histone H2B (H2Bub1) was correlated with poor prognosis of CRC patients and, accordingly, H2Bub1 was suggested as a tumor-suppressive mark. Surprisingly, our previous work revealed that the H2B ubiquitin ligase RING finger...

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PMID: 31266541
DOI: 10.1186/s13148-019-0698-x

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