Article
Glutamate E15 and E171 are Hotspots in p60TRP-Related Cancer.
Cancer investigation - 1 Jan 2016
Kutzner Arne, Heese Klaus
Abstract excerpt
RAS protein is a small G protein linked to multiple G protein-coupled receptor (GPCR) signaling cascades and is responsible for various types of cancer, but to this day, Ras is considered "undruggable." Multiple alternative regulators of G protein signaling (RGS) pathways have become the focus of ongoing efforts to identify new cancer therapeutics. We analyzed human cancer genome datasets and describe p60TRP, a...
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