Article

Missense mutations in the calcium-activated chloride channel TMEM16A promote tumor growth by activating oncogenic signaling in Human Cancer

2023-06-22

Abstract excerpt

<h4>ABSTRACT</h4> The calcium-activated chloride channel TMEM16A is overexpressed in several tumors. This condition is associated with a poor survival prognosis but highlights TMEM16A’s potential as a biomarker and target for anti-cancer therapies. Numerous somatic mutations of TMEM16A have been reported; however, their potential and molecular mechanism of oncogenesis are unknown. Here, we investigate the functio...

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Literature Corpus work: bb665b0f-5461-5fe5-94d6-280900208ccc
DOI: 10.1101/2023.06.21.545912

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