Article
Somatic mutations in GRM1 in cancer alter metabotropic glutamate receptor 1 intracellular localization and signaling.
Molecular pharmacology - 1 Apr 2013
Esseltine Jessica L, Willard Melinda D, Wulur Isabella H, Lajiness Mary E, Barber Thomas D, Ferguson Stephen S G
Abstract excerpt
The activity of metabotropic glutamate receptors (mGluRs) is known to be altered as the consequence of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease. However, little attention has been paid to this receptor family's potential link with cancer. Recent reports indicate altered mGluR signaling in various tumor types, and several somatic mutations in mGluR1a in lung cancer were...
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