Article
A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS.
Neuron - 28 Apr 2011
Wu Zhuhao, Sweeney Lora B, Ayoob Joseph C, Chak Kayam, Andreone Benjamin J, Ohyama Tomoko, Kerr Rex, Luo Liqun, Zlatic Marta, Kolodkin Alex L
Abstract excerpt
Longitudinal axon fascicles within the Drosophila embryonic CNS provide connections between body segments and are required for coordinated neural signaling along the anterior-posterior axis. We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b....
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