Article
Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting.
Neuron - 8 Dec 2011
Sweeney Lora B, Chou Ya-Hui, Wu Zhuhao, Joo William, Komiyama Takaki, Potter Christopher J, Kolodkin Alex L, Garcia K Christopher, Luo Liqun
Abstract excerpt
During assembly of the Drosophila olfactory circuit, projection neuron (PN) dendrites prepattern the developing antennal lobe before the arrival of axons from their presynaptic partners, the adult olfactory receptor neurons (ORNs). We previously found that levels of transmembrane Semaphorin-1a, which acts as a receptor, instruct PN dendrite targeting along the dorsolateral-ventromedial axis. Here we show that two...
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