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Article

Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease.

Experimental neurology - 1 Apr 2016

Carrasco Dario I, Bahr Ben A, Seburn Kevin L, Pinter Martin J

Abstract excerpt

In several animal models of motor neuron disease, degeneration begins in the periphery. Clarifying the possible role of Schwann cells remains a priority. We recently showed that terminal Schwann cells (TSCs) exhibit abnormalities in postnatal mice that express mutations of the SOD1 enzyme found in inherited human motor neuron disease. TSC abnormalities appeared before disease-related denervation commenced and the...

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Identifiers

PMID: 26853136
DOI: 10.1016/j.expneurol.2016.02.002
PMCID: PMC4788963

Genes

SOD1

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