Article
The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease.
Molecular and cellular neurosciences - 1 Jan 2000
De Winter Fred, Vo Tam, Stam Floor J, Wisman Liselijn A B, Bär Peter R, Niclou Simone P, van Muiswinkel Freek L, Verhaagen Joost
Abstract excerpt
Neuromuscular synapses differ markedly in their plasticity. Motor nerve terminals innervating slow muscle fibers sprout vigorously following synaptic blockage, while those innervating fast-fatigable muscle fibers fail to exhibit any sprouting. Here, we show that the axon repellent Semaphorin 3A is differentially expressed in terminal Schwann cells (TSCs) on different populations of muscle fibers: postnatal,...
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