Article
Defective ensheathment of motoric nerves in the Splotch mutant mouse.
Acta anatomica - 1 Jan 1990
Franz T
Abstract excerpt
Mouse embryos, homozygous for mutations at the Splotch locus, are afflicted with spina bifida and disturbances of neural-crest-derived tissues, e.g. spinal ganglia and pigment cells. The development of Schwann cells is affected in homozygotes to a varying degree along the rostrocaudal axis. In cervical motoric roots, nerves are associated with apparently normal Schwann cells. At the thoracic level,...
Topics
- Animals
- Embryo, Mammalian
- Homozygote
- Male
- Mice
- Mice, Mutant Strains
- Microscopy, Electron
- Motor Neurons
- Myelin Sheath
- Neural Crest
- Phenotype
- Schwann Cells