Article
Huntington disease.
Nature reviews. Disease primers - 23 Apr 2015
Bates Gillian P, Dorsey Ray, Gusella James F, Hayden Michael R, Kay Chris, Leavitt Blair R, Nance Martha, Ross Christopher A, Scahill Rachael I, Wetzel Ronald, Wild Edward J, Tabrizi Sarah J
Abstract excerpt
Huntington disease is devastating to patients and their families - with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course, and a combination of motor, cognitive and behavioural features. The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene that encodes the protein huntingtin. In mutation carriers, huntingtin is produced...
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