Article
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer.
Cell - 11 Jun 2004
Kraus Manfred, Alimzhanov Marat B, Rajewsky Nikolaus, Rajewsky Klaus
Abstract excerpt
We previously showed that type I interferon-induced, Cre-mediated ablation of surface BCR expression in mature B cells through Ig-heavy chain deletion results in apoptosis of these cells. This led to the hypothesis that survival signals from the BCR are vital for mature B cells. Here, we test two critical assumptions of this model. First, we demonstrate loss of mature B cells upon induced mutation of a signaling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.