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Article

Immunogenetics of complement in mixed cryoglobulinaemia.

Clinical and experimental rheumatology - 1 Jan 2000

Menegatti Elisa, Messina Margherita, Oddone Valentina, Rubini Elena, Sciascia Savino, Naretto Carla, Baldovino Simone, Roccatello Dario

Abstract excerpt

OBJECTIVES: A low C4 level is one of the hallmarks of mixed cryoglobulinaemia (MC). However, several reports suggest that other factors may be involved in C4 depletion. The C4 gene is located in a multiallelic CNV locus in the human MHC region. We studied the C4 gene copy number (GCN) and both C4A and C4B isotypes, as well as the presence of the hypofunctional C4A6 allotype (rs41315824) and C4A0 allotype...

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PMID: 26842656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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