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Article

Molecular analysis of complement component C4 gene copy number.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Castley Alison S L, Martinez O Patricia

Abstract excerpt

Classical, alternative, or lectin pathways may activate the complement system cascade. The classical pathway includes the C4 protein and functions in the prevention of immune complex precipitation and in clearance of immune complexes.Two isotypes of C4-C4A and C4B-are coded by genes located at two loci within the major histocompatibility complex (MHC) on chromosome 6. While these isotypes share over 99% amino...

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PMID: 22665233
DOI: 10.1007/978-1-61779-842-9_9

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Source receipt: pubmed, retrieved 7 Sept 2026.

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