Article
Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies.
Annals of the rheumatic diseases - 1 Feb 2023
Zhou Danlei, King Emily H, Rothwell Simon, Krystufkova Olga, Notarnicola Antonella, Coss Samantha, Abdul-Aziz Rabheh, Miller Katherine E, Dang Amanda, Yu G Richard, Drew Joanne, Lundström Emeli, Pachman Lauren M, Mamyrova Gulnara, Curiel Rodolfo V, De Paepe Boel, De Bleecker Jan L, Payton Antony, Ollier William, O'Hanlon Terrance P, Targoff Ira N, Flegel Willy A, Sivaraman Vidya, Oberle Edward, Akoghlanian Shoghik, Driest Kyla, Spencer Charles H, Wu Yee Ling, Nagaraja Haikady N, Ardoin Stacy P, Chinoy Hector, Rider Lisa G, Miller Frederick W, Lundberg Ingrid E, Padyukov Leonid, Vencovský Jiří, Lamb Janine A, Yu Chack-Yung
Abstract excerpt
BACKGROUND: Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle fibres, chronic weakness and fatigue. While complement-mediated destruction of capillary endothelia is implicated in paediatric and adult dermatomyositis, the...
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