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Article

Human Complement C4B Allotypes and Deficiencies in Selected Cases With Autoimmune Diseases.

Frontiers in immunology - 1 Jan 2021

Zhou Danlei, Rudnicki Michael, Chua Gilbert T, Lawrance Simon K, Zhou Bi, Drew Joanne L, Barbar-Smiley Fatima, Armstrong Taylor K, Hilt Miranda E, Birmingham Daniel J, Passler Werner, Auletta Jeffrey J, Bowden Sasigarn A, Hoffman Robert P, Wu Yee Ling, Jarjour Wael N, Mok Chi Chiu, Ardoin Stacy P, Lau Yu Lung, Yu Chack Yung

Abstract excerpt

Human complement C4 is one of the most diverse but heritable effectors for humoral immunity. To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including the frequent genetic deficiency of C4A and/or C4B isotypes. We demonstrated the diversities of C4A and C4B proteins and their gene copy number variations (CNVs) in...

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Identifiers

PMID: 34764957
DOI: 10.3389/fimmu.2021.739430
PMCID: PMC8577214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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