Article
Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short, and RCCX modules: elucidation of C4 CNVs in 50 consanguineous subjects with defined HLA genotypes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2007
Wu Yee Ling, Savelli Stephanie L, Yang Yan, Zhou Bi, Rovin Brad H, Birmingham Daniel J, Nagaraja Haikady N, Hebert Lee A, Yu C Yung
Abstract excerpt
Recent comparative genome hybridization studies revealed that hundreds to thousands of human genomic loci can have interindividual copy number variations (CNVs). One of such CNV loci in the HLA codes for the immune effector protein complement component C4. Sensitive, specific, and accurate assays to interrogate the C4 CNV and its associated polymorphisms by using submicrogram quantities of genomic DNA are needed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.