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A TB40/E-Derived Human Cytomegalovirus Genome with an Intact US-Gene Region and a Self-Excisable BAC Cassette for Immunological Research

1 Nov 2017

Abstract excerpt

For immunological research on the human cytomegalovirus (HCMV), a virus that combines the broad cell tropism of clinical isolates, efficient replication in cell culture, the complete set of MHC-I modulator genes, and suitability for genetic engineering is desired. Here, we aimed to generate a genetically complete derivative of HCMV strain TB40/E as a bacterial artificial chromosome (BAC) with a self-excisable BAC...

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PMID: 29185920
DOI: 10.2144/000114606

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