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Article

Role of connexin32 and beta-catenin in tumor promotion in mouse liver.

Toxicologic pathology - 1 Jan 2000

Schwarz Michael, Wanke Ines, Wulbrand Ulrich, Moennikes Oliver, Buchmann Albrecht

Abstract excerpt

Tumor promoters are nonmutagenic chemicals that increase the probability of cancer by accelerating the clonal expansion of cells transformed during tumor initiation. The molecular mechanisms underlying this process are only partly understood but interference with signaling pathways regulating cell division and/or cell death is likely to be important. Ras- and beta-Catenin-dependent signaling is important for both...

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Identifiers

PMID: 12597453
DOI: 10.1080/01926230390173932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Role of connexin32 and beta-catenin in tumor promotion in mouse liver.PMID 12597453Read ↗

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Involvement of gap junctions in tumor suppression: analysis of genetically-manipulated mice.Semantic proximity Read ↗

Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.Semantic proximity Read ↗

The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.Semantic proximity Read ↗

Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.Semantic proximity Read ↗

Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.Semantic proximity Read ↗

Background lesions during a 24-month observation period in connexin 32-deficient mice.Semantic proximity Read ↗

Connexins as targets for cancer chemoprevention and chemotherapy.Semantic proximity Read ↗

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.Semantic proximity Read ↗

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.Semantic proximity Read ↗

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors.Semantic proximity Read ↗

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