WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

Abstract excerpt

Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in the incidence of CC, little progress has been made toward the development of treatments for this cancer. Here we utilized human tissue; CC cell xenografts; a p53-deficient transgenic mouse model; and a non-transgenic, chemically induced rat model of CC that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to MicroRNA in disease regulation
• Share to Peptidase Inhibition and Analysis
• Share to Wnt/β-catenin signaling in development and cancer