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Article

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.

The Journal of experimental medicine - 8 Feb 2016

Klein Claudius, Zwick Anabel, Kissel Sandra, Forster Christine Ulrike, Pfeifer Dietmar, Follo Marie, Illert Anna Lena, Decker Sarah, Benkler Thomas, Pahl Heike, Oostendorp Robert A J, Aumann Konrad, Duyster Justus, Dierks Christine

Abstract excerpt

JAK2V617F(+) myeloproliferative neoplasms (MPNs) frequently progress into leukemias, but the factors driving this process are not understood. Here, we find excess Hedgehog (HH) ligand secretion and loss of PTCH2 in myeloproliferative disease, which drives canonical and noncanonical HH-signaling. Interestingly, Ptch2(-/-) mice mimic dual pathway activation and develop a MPN-phenotype with leukocytosis (neutrophils...

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Identifiers

PMID: 26834157
DOI: 10.1084/jem.20150556
PMCID: PMC4749921

Genes

PTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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