Article
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.
Leukemia - 1 Oct 2018
Burns Melissa A, Liao Zi Wei, Yamagata Natsuko, Pouliot Gayle P, Stevenson Kristen E, Neuberg Donna S, Thorner Aaron R, Ducar Matthew, Silverman Emily A, Hunger Stephen P, Loh Mignon L, Winter Stuart S, Dunsmore Kimberly P, Wood Brent, Devidas Meenakshi, Harris Marian H, Silverman Lewis B, Sallan Stephen E, Gutierrez Alejandro
Abstract excerpt
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic intervention. Here, we show that Hedgehog pathway mutations predict chemotherapy resistance in human T-ALL, and drive...
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