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Targeting hedgehog signaling in myelofibrosis and other hematologic malignancies

5 Mar 2014

Abstract excerpt

Treatment of myelofibrosis (MF), a BCR-ABL-negative myeloproliferative neoplasm, is challenging. The only current potentially curative option, allogeneic hematopoietic stem cell transplant, is recommended for few patients. The remaining patients are treated with palliative therapies to manage MF-related anemia and splenomegaly. Identification of a mutation in the Janus kinase 2 (JAK2) gene (JAK2 V617F) in more...

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PMID: 24598114
DOI: 10.1186/1756-8722-7-18

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