LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.

doi:10.1158/2159-8290.CD-20-1353

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Article

LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms.

Cancer discovery - 1 Jun 2021

Marinaccio Christian, Suraneni Praveen, Celik Hamza, Volk Andrew, Wen Qiang Jeremy, Ling Te, Bulic Marinka, Lasho Terra, Koche Richard P, Famulare Christopher A, Farnoud Noushin, Stein Brady, Schieber Michael, Gurbuxani Sandeep, Root David E, Younger Scott T, Hoffman Ronald, Gangat Naseema, Ntziachristos Panagiotis, Chandel Navdeep S, Levine Ross L, Rampal Raajit K, Challen Grant A, Tefferi Ayalew, Crispino John D

Abstract excerpt

The myeloproliferative neoplasms (MPN) frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion of LKB1/Stk11 led to enhanced in vitro self-renewal of murine MPN cells. Deletion of Stk11 in a mouse MPN model caused rapid lethality with enhanced fibrosis,...

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PMID: 33579786
DOI: 10.1158/2159-8290.CD-20-1353
PMCID: PMC8178182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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