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Article

Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2.

Neuron - 17 Feb 2016

Hoffman Ellen J, Turner Katherine J, Fernandez Joseph M, Cifuentes Daniel, Ghosh Marcus, Ijaz Sundas, Jain Roshan A, Kubo Fumi, Bill Brent R, Baier Herwig, Granato Michael, Barresi Michael J F, Wilson Stephen W, Rihel Jason, State Matthew W, Giraldez Antonio J

Abstract excerpt

Autism spectrum disorders (ASDs) are a group of devastating neurodevelopmental syndromes that affect up to 1 in 68 children. Despite advances in the identification of ASD risk genes, the mechanisms underlying ASDs remain unknown. Homozygous loss-of-function mutations in Contactin Associated Protein-like 2 (CNTNAP2) are strongly linked to ASDs. Here we investigate the function of Cntnap2 and undertake...

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Identifiers

PMID: 26833134
DOI: 10.1016/j.neuron.2015.12.039
PMCID: PMC4766582

Genes

CNTNAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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