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Article

Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish.

International journal of molecular sciences - 30 Aug 2024

Wang Yongxin, Sun Xiaoyun, Xiong Bo, Duan Ming, Sun Yuhua

Abstract excerpt

Human mutations of ADNP and ADNP2 are known to be associated with neural developmental disorders (NDDs), including autism spectrum disorders (ASDs) and schizophrenia (SZ). However, the underlying mechanisms remain elusive. In this study, using CRISPR/Cas9 gene editing technology, we generated adnp and adnp2 mutant zebrafish models, which exhibited developmental delays, brain deficits, and core behavioral features...

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Identifiers

PMID: 39273418
DOI: 10.3390/ijms25179469
PMCID: PMC11395604

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