Article

Estradiol modulates neuronal network hyperexcitability in select NDD risk genes

2026-02-18

Abstract excerpt

<h4>ABSTRACT</h4> The biological basis for the male sex bias in autism spectrum disorder (ASD) is poorly understood. Differential exposure to sex hormones during neurodevelopment has been proposed as a potential modulator of risk. To test the hypothesis that early exposure to the principal biologically active estrogen, 17β-estradiol, confers a protective effect against mutations in ASD and neurodevelopmental diso...

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Literature Corpus work: 88b1b99b-276c-5a12-bfcc-8f2a5b1311a0
DOI: 10.64898/2026.02.18.706588

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