Article

ToxCast chemical library screen identifies diethanolamine as an activator of Wnt signaling

2021-02-15

Abstract excerpt

Numerous autism spectrum disorder (ASD) risk genes are associated with Wnt signaling, suggesting that brain development may be especially sensitive to genetic perturbation of this pathway. Additionally, valproic acid, which modulates Wnt signaling, increases risk for ASD when taken during pregnancy. We previously found that an autism-linked gain-of-function UBE3A T485A mutant construct hyperactivated canonical Wn...

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Literature Corpus work: 1c15afe3-9566-5b60-84b1-853e081cd8b4
DOI: 10.1101/2021.02.15.430319

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