Article
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.
American journal of human genetics - 1 Jan 2008
Alarcón Maricela, Abrahams Brett S, Stone Jennifer L, Duvall Jacqueline A, Perederiy Julia V, Bomar Jamee M, Sebat Jonathan, Wigler Michael, Martin Christa L, Ledbetter David H, Nelson Stanley F, Cantor Rita M, Geschwind Daniel H
Abstract excerpt
Autism is a genetically complex neurodevelopmental syndrome in which language deficits are a core feature. We describe results from two complimentary approaches used to identify risk variants on chromosome 7 that likely contribute to the etiology of autism. A two-stage association study tested 2758 SNPs across a 10 Mb 7q35 language-related autism QTL in AGRE (Autism Genetic Resource Exchange) trios and found...
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