Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.

doi:10.1073/pnas.2518846123

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Article

Pharmaco-behavioral profiling identifies suppressors of autism gene-associated phenotypes in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2026

Jamadagni Priyanka, Dai Yi, Liu Yunqing, Weinschutz Mendes Hellen, Pruitt April, Khan Suha, Yang Liang, Huang Tzu-Chieh, Huang Xiayuan, Deans P J Michael, Balafkan Novin, Zhao Dejian, Xu Gang, Liu Yihan, Li Ningshan, Wu Weimiao, Fitzpatrick Sarah E, Neelakantan Uma, Chen Tianying, Szialta Christina, Jin David S, Lacadie Cheryl M, Umlauf Sheila, Papademetris Xenophon, Surovtseva Yulia V, Brennand Kristen J, Wang Zuoheng, Hoffman Ellen J

Abstract excerpt

Pharmaco-behavioral screens in scalable in vivo systems have critical advantages for drug discovery relevant to large-effect autism spectrum disorder (ASD) genes. Here, we establish a database and open-source website of the behavioral signatures of 520 US Food and Drug Administration (FDA)-approved drugs using high-throughput assays of basic sensory processing and arousal behaviors in larval zebrafish. By...

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Identifiers

PMID: 41838920
DOI: 10.1073/pnas.2518846123
PMCID: PMC13012064

Genes

DYRK1A
SCN2A

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