Article
Sensor histidine kinase is a β-lactam receptor and induces resistance to β-lactam antibiotics.
Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2016
Li Lu, Wang Qiyao, Zhang Hui, Yang Minjun, Khan Mazhar I, Zhou Xiaohui
Abstract excerpt
β-Lactams disrupt bacterial cell wall synthesis, and these agents are the most widely used antibiotics. One of the principle mechanisms by which bacteria resist the action of β-lactams is by producing β-lactamases, enzymes that degrade β-lactams. In Gram-negative bacteria, production of β-lactamases is often induced in response to the antibiotic-associated damage to the cell wall. Here, we have identified a...
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